Molecular features of pediatric maB-NHL classified by gene expression profiling using the mBL index.9 Genomic complexity of the cases is shown as bar plots on top of the panels, with complexity increasing with height. Below, the plot with the orange background shows the mBL-index on the y-axes indicating the similarity to the core-BLs {Hummel, Bentink, et al 2006 1205 /id} (gray box on the left to the mBL-index plot). The vertical lines delineate the 3 groups of lymphomas (mBL on the left, intermediate in the middle, and non-mBL on the reight) and the dashed horizontal lines indicate the index-score cutoffs defining the mBL group (0.95) and the non-mBL group (0.05) according to the mBL-index.9 Below, the heat map shows the gene-expression levels of the 58 mBL-signature genes, with 1 gene shown per row. Bright blue indicates a low level of expression (3 SD below the average of all cases), bright yellow indicates a high level of expression (3 SD above the average), and black the average level of expression across all samples. The cases are ordered from left to right on the basis of decreasing mBL-signature index score, given again below the heat map. Green represents a high index score (mBL), and red a low index score (non-mBL). The color gradient of the intermediate cases highlights the continuous transition of the index score between the mBL and non-mBL cases. The myc translocation partners are shown according MYC break (bright green) and MYC-breakpoint absent (red). The histologic diagnosis is shown in the panel below. Bright green indicates core-Burkitt lymphoma; dark green, Burkitt lymphoma; red, diffuse large-B-cell lymphoma; blue, follicular lymphoma and gray, unclassifiable mature aggressive B-cell lymphoma. The proliferation-index is coded with green for Ki-67 greater than 95% and red for Ki-67 less than 95%. Finally, BCL2 protein expression is indicated in green for negativity and red for positivity. White bars indicate not assessable.
