The risk of late infections during remission. Bars represent the risk of serious (grade ≥ 3, viral, or opportunistic) infections for each year of ongoing remission. The infection risk was highest in the first year and rapidly declined to a baseline risk of less than 1.5% per year from the third year onward. The colored dots represent individual episodes per year; crosses, infection episodes that were fatal. The occurrence of opportunistic infections was limited to the first year, and varicella-zoster reactivation was limited predominantly to the first 2 years.