Zoledronate and IL-2 promote cellular responses in the CD56⁺ subset: abrogation of cytokine responses after depletion of CD14⁺ cells. CD56⁺ cells or CD56⁺ cells depleted of CD14⁺ cells were either left untreated or stimulated with IL-2, zoledronate, or zoledronate plus IL-2. IFN-γ, IL-1β, and TNF-α determined in culture supernatants on day 5 were present in replete cultures but strongly diminished in CD14-depleted cultures. FSC/SCC analysis of control cultures confirmed depletion of the DC population (top). Results shown are combined from 3 independent experiments. Error bars indicate the SD of mean from triplicate cultures.