The anti-A20 Id mAb + CpG combination therapy prevents the emergence of Id-negative tumor escapees. Mice that were cured from anti-A20 Id mAb + CpG combination therapy or naive Balb/c mice were inoculated with 3 different tumor cell types subcutaneously on 3 separate locations of each mouse: 107 A20 cells, 107 escapee A20 cells, or 5 × 105 CT26. Each line is representative of a group consisting of 10 mice.