Comparison of outcomes after islet transplantation into the BM and liver in minimal mass models. C57BL/6 recipients were transplanted with 125 or 250 syngeneic equivalent islets either into the portal vein (intraliver: 125 EI n = 20, 250 EI n = 21) or into the BM (intra-BM: 125 EI n = 31, 250 EI n = 25). Mice that died due to the surgical procedure (4 of 56 and 8 of 41, respectively, for intra-BM and intraliver) were excluded from the analysis. (A) Kaplan-Meier analysis for the gain of normoglycemia (< 200 mg/dL). (B) Kaplan-Meier survival analysis. Differences between the intra-BM and intraliver models were tested using the log rank statistic adjusted for islet number.