Graft survival and long-term glucose metabolism after islet transplantation in BM and liver. (A) Blood glucose profile of normal C57BL/6 mice (Ctrl, white; n = 11), and mice that achieved normoglycemia after receiving islets intra-BM (dark gray; n = 47) or intraliver (gray; n = 32). Data are expressed as mean (line) and ±1 SD (area). ^aStatistical analysis was performed by tests of repeated measures ANOVA considering intervals of 2 months. ^bStatistical analysis was performed by tests of repeated measures ANOVA adjusted for islet number considering intervals of 2 months. *P < .05; **P > .001; ns = not significant. (B) Fasting glycemia (mg/dL), insulin (pM), glucagon (pM), β-cell function (HOMA2-B, %), and insulin resistance (HOMA-IR) in normal C57BL/6 mice (Ctrl, white), and mice that achieved normoglycemia after receiving islets intra-BM (dark gray; n = 47) or intraliver (gray; n = 32). Assays were performed 6 to 9 months after islet infusion. Data are expressed as box plots. Statistical analysis was performed using 1-way ANOVA test, followed by Bonferroni post hoc t test. *P < .05; **P < .001.