Blood levels of glucose and the glucose elimination constant (KG) during IVGTT after islet transplantation in BM and in liver. Mice were monitored by measuring glucose tolerance after IVGTT at 1, 3, 6, and 12 months after transplantation. Shown are IVGTT glycemic profile and glucose tolerance (KG_1-15 and KG_1-60) in mice that achieved normoglycemia (28 of 47 for intra-BM and 10 of 32 for intraliver). The yellow shaded area represents the range of values in healthy control mice (Ctrl, n = 11). Data are expressed as mean for glycemic profile and boxplots for glucose tolerance. Statistical analysis was performed using 1-way ANOVA test, followed by Bonferroni post hoc t test. *P < .01 versus control.