The LAIR-1/collagen complex. (A) Surface representation of LAIR-1 showing the effect of mutations on collagen binding: red indicates strong decrease; pink, moderate decrease; orange, moderate decrease in the plate adhesion assay only; and blue, no effect. (B) Surface representation of LAIR-1 with ribbon representations of collagen peptide III-30 models from the 2 highest scoring docking solutions (supplemental Table 3), shown in red and yellow. LAIR-1 residues that contact the docked peptides are shown in green. (C) Close-up of the putative collagen-binding site, showing in sticks LAIR-1 residues that are in contact with the docked collagen peptide. Residues that affect collagen binding when mutated are shown in blue. The collagen peptide is shown in semitransparent surface representation.