Loss of bmf enhances the severity of Eμ-myc lymphomas. (A) Numbers of total leukocytes in the blood of moribund mice of the indicated genotypes. The leukocyte counts were significantly greater in bmf^−/−Eμ-myc mice than in wt Eμ-myc mice (mean leukocyte count in Eμ-myc/bmf^−/− mice was 263 ± 251 × 10⁶/mL vs 58 ± 67 × 10⁶/mL in Eμ-myc mice). Diamonds represent individual blood count of mice and bars the corresponding means. (B) Spleen weights of moribund mice of the indicated genotypes. Loss of bmf but not loss of bad lead to a significant increase in spleen size in moribund mice (mean spleen weight 0.599 ± 0.253 g in Eμ-myc/bmf^−/− vs 0.395 ± 0.140 g in Eμ-myc or 0.428 ± 0.160 g in Eμ-myc/bad^−/−). Diamonds represent individual spleen weights in mice of the indicated genotypes with bars indicating the corresponding means. *P < .01, **P < .001, ***P < .001 compared with Eμ-myc.