BCL6-silencing gene signature is significantly enriched in BCL6 target genes. Gene set enrichment according to up-regulation in response to BCL6 silencing was measured for (A) the targets identified as BCL6-anti-coexpressed genes with BCL6-bound promoters according to ChIP-on-chip analysis and (B) the subset of targets that is also inferred by ARACNe. GSEA computed the significance of up-regulation in BCL6-silencing versus control experiments by t test (top meter in each panel) for each target set (second meter). Leading edge analysis was used to predict responsive BCL6 targets (left of vertical line in each panel) and enrichment score (ES) P values were estimated by the use of extrapolation over 100 000 sample-permutation tests.