Plg-RKT regulates cell surface plasminogen activation. Plasminogen activation was determined after 12 minutes as described in “Plasminogen activation assay” in either the presence or absence of either undifferentiated Hoxa9-ER4 progenitor cells or M-CSF–differentiated Hoxa9-ER4 cells and in the presence of either rat anti–Plg-RKT mAb 35B10 (■) or isotype control rat IgG2a (□). ***P < .001, compared with the corresponding isotype control.