Pharmacokinetics and fibrinolytic activity of scFv/uPA-T fusion protein and soluble uPA in mice. (A) Blood clearance of ¹²⁵I-scFv/uPA-T after intravenous injection. Inset: Distribution of ¹²⁵I-uPA 1 hour after injection. (B) Spontaneous lysis of clots formed from blood obtained after intravenous injection of scFv/uPA-T (4 mg/kg, 0.95μM initial concentration in blood, ▨) or PBS (- - -). N = 4 per group; P < .05 versus saline injected control.