Prophylactic thrombolysis by scFv/uPA-T in venous thrombosis. Saline (A), untargeted uPA (B), or an equimolar dose of scFv/uPA-T (C-D) was injected intravenously in the jugular vein 1 or 24 hours before injury to the contralateral jugular vein by application of FeCl₃. Explanations are as in Figure 5. Panel E shows analysis of the data collected from each group presented as percent of pre-injury level of the blood flow in the jugular vein during the first 30 minutes after induction of injury in mice pretreated with uPA or scFv/uPA-T 1 or 24 hours before the injury. In panel E, n = 9 per group, P < .05.