Defects in Alox15 hematopoiesis are cell-autonomous. (A) Assessment of hematopoietic reconstitution of lethally irradiated B6.SJL mice 16 weeks after engraftment with 1 × 106 B6 or Alox15 BM cells (n = 6). (B) Hematopoietic reconstitution of lethally irradiated B6 and Alox15 mice 16 weeks after engraftment of 1 × 106 B6.SJL BM cells (n = 3); *P < .05, * *P < .01 compared with wild-type. All error bars represent the average (± SEM).