Structural representation of mammalian LDLR family members. The LDLR family consists of at least 8 homologous transmembrane receptors in mammals, which are composed of the same protein domains with similar topological organizations. Coagulation factor VIII directly binds to LDLR, LRP-1, VLDLR, and megalin (LRP-2) via their clusters of complement-type repeats.^3,5-8  ApoER2 indicates apolipoprotein E receptor 2; and MEGF7, multiple EGF repeat-containing protein 7.