WT mice receiving CCR7^−/− combined HSC and MPC HSCT (CCR7^−/−→WT) have decreased fungal burden and increased survival, compared with WT mice receiving a WT-combined HSC and MPC HSCT (WT→WT). Lethally irradiated WT mice were reconstituted with 6.0 × 10² HSCs, 1.0 × 10⁴ CMPs, and 1.0 × 10⁴ GMPs from either WT or CCR7^−/− mice 14 days before an intratracheal challenge with 2.0 × 10⁶ conidia. Mice were followed for survival or harvested at 48 hours after fungal challenge. (A-F) Histologic analysis of lung tissue 2 days after conidia challenge. H&E staining of uninfected lungs (A-B) or 48 hours after conidia challenge (C-D). (E-F) Representative GMS-stained sections from WT (E) or CCR7^−/− (F) mice after conidial challenge; fungal elements are stained in black. Original magnification was 10× for all sections. (G) Survival of WT mice receiving WT or CCR7^−/− HSCs and MPCs (n = 4-5 mice per group, representative of 2 experiments).