Ingenuity Pathway Analysis of differentially expressed genes in patients with FHL. The top 15 over-represented canonical pathways of the down-regulated (A) and up-regulated (B) genes found in FHL patients compared with controls. Canonical pathways for probe sets indicate down-regulated genes (A) and up-regulated genes (B) that were identified using analysis of variance (P < .05) and fold change (2-fold) cut-offs. Category names are presented on the y-axis. The x-axis indicates the −log (P value) of the over-representation analysis. Orange squares represent ratios calculated from the number of genes in the dataset of a given pathway divided by the total number of molecules in the canonical pathway.