Impaired mobilization despite decreased CXCL12 in Vdr^−/− BM. Cxcl12 mRNA in BM and CXCL12 in BM extracellular fluid (BMEF) was drastically decreased, despite highly impaired mobilization in Vdr^−/−. (A) mRNA (n = 5-6) and protein (n = 6-9) in mice fed with a normal diet. (B) mRNA (n = 4-5) and protein (n = 4-5) in mice fed with a high-calcium diet. (C) AMD3100-induced mobilization in Vdr^−/−. CFU-Cs in mice fed with a normal diet (PBS: n = 3-5; AMD3100: n = 6). *P < .05; **P < .01; ***P < .001.