Distribution of the chromosomal and molecular lesions in FA patients. Somatic copy-number gains, losses, and UPD are color-encoded and plotted vertically in chromosomal order for each patient. Samples were clustered horizontally according to the progression stage groups in the BM and then by visual inspection to cluster the abnormalities. The recurrent abnormalities and a selection of relevant genes are indicated on the right part of the figure. 1q+ and 3q+ are specific from FA and are indicated in red, the other abnormalities can be found in non-FA MDS/AML and are indicated in black. Oncogenes and tumor suppressor gene mutation screen data are shown on the lowest panel of the figure; the dark gray background and brown boxes indicate which samples were screen and presence of mutations, respectively.