Fever curves after DLI are correlated with clinical events. A typical temperature curve from an engrafting patient is shown in green. Curves from the 2 patients with anti-donor antibodies who rejected their grafts are shown in red and blue. The boundary between the febrile and afebrile ranges (100.4°F) is shown by the horizontal solid black line. The afebrile range is shaded gray. Engrafting patients generally developed fever within 24 hours after DLI. The fever spikes persisted despite the use of acetaminophen and other comfort measures until after the second dose of CY. In the setting of anti-donor antibodies, patients developed fever within a few hours of the DLI, rapidly defervesced, and remained afebrile thereafter.