Adjusted mean differences between CML patients and their respective control groups by age categories. (A) Physical health and (B) mental health. A score below 0 line means worse outcomes for CML patients. Note that connecting lines among SF-36 outcomes are plotted only for descriptive purposes. *Statistically significant after Bonferroni adjustment (adjusted α = 0.05/8 = 0.00625). Statistical significance refers to the group specific adjusted mean differences of SF-36 scores between CML patients and matched control subjects. †Mean difference between CML patients by age group and the respective matched control subjects adjusted for age, gender, education, geographical area, and marital status. A negative sign indicates worse outcomes for CML patients. ‡Exceeds minimally important difference (ie, 8 points for the SF-36 scales and 2 points for the PCS and MCS scores). §Statistically significant (α = 0.05).