FeCl₃-induced thrombosis in the carotid artery. (A) Percentage of mice showing stable, unstable, or no thrombi in response to exposure of the carotid artery to 10% FeCl₃ for 4 minutes (left) or 40% FeCl₃ for 2.5 minutes (right). n = 5 for all of the indicated study groups. (B) Flow traces recorded after exposure of the carotid artery of a WT (WT, black line), WT + clopidogrel (WT + clop., gray line), or CalDAG-GEFl^−/− mouse (KO, dotted black line) to 40% FeCl₃ for 2.5 minutes. Note the repeated changes in blood flow in the clopidogrel-treated WT mouse, indicative of the generation of near-occlusive thrombi followed by embolization.