CD47 is an integrin-associated protein and a ligand for the phagocytosis-inhibitory receptor SIRPα (left). Various types of NHL overexpress CD47, which correlates with poor prognosis. In this issue of Blood, Chao et al show that CD47 is more prominently expressed by disseminated lymphoma cells and that targeting CD47 with a blocking antibody or by RNAi impairs chemokine-controlled migration, promotes macrophage-mediated phagocytosis and prevents dissemination of the malignant B cells (right).