Clinical effect of lesions detected by SNP-A karyotyping analysis in combination with MC and new lesions detected by SNP-A regardless of MC results. Patients with new defects (red line) detected by the combination MC or SNP-A had worse OS (A), EFS (B), and PFS (C) than patients with no defects (black line) detected by both techniques. Patients with new lesions detected by SNP-A regardless of MC results showed worse OS (D), EFS (E), and PFS (F) than patients with an unchanged karyotype. In addition, SNP-A–identified lesions had an effect on OS in patients in the low-risk IPSS group (G) but not on EFS (H) and PFS (I). New SNP-A–detected defects did not affect outcomes in the high-risk IPSS group (J, K, and L). Tables represent the number at risk over time. Characteristics of censored patients have been presented in supplemental Table 4.