New prognostic risk groups based on combined MC and SNP-A analyses. SNP-A was able to further delineate cytogenetic risk groups determined by MC as defined by IPSS (A-B). Four prognostic risk groups, namely favorable, intermediate-1, intermediate-2, and unfavorable were defined with the use of the combined karyotypic analysis by MC and SNP-A (C-D). †Favorable indicates good cytogenetics and no additional lesions detected by SNP-A. Intermediate-1 indicates good cytogenetics and additional SNP-A lesions detected, or intermediate cytogenetics and no additional lesions by SNP-A. Intermediate-2 indicates intermediate cytogenetics and additional lesions detected, or poor cytogenetics and no additional lesions detected by SNP-A. Unfavorable indicates poor cytogenetics by MC and additional lesions detected by SNP-A.