Figure 6
Figure 6. ETV6-RUNX1 deregulates EPOR expression, activates STAT5 signaling pathways, and enhances BCL-XL expression in a human preleukemic cell model. (A) Experimental schema: human CD34+ cells were isolated from normal cord blood and infected with an ETV6-RUNX1–expressing lentivirus. Cells were primed for B-cell differentiation for up to 5 days. (B) GFP+ (ETV6-RUNX1+) cells were analyzed for EPOR expression by FACS. EV indicates empty vector. (C) GFP+ (ETV6-RUNX1+) cells were analyzed for EPOR expression by Western blot. (D) GFP+ (ETV6-RUNX1+) cells were analyzed for BCL-XL expression and Western blot.

ETV6-RUNX1 deregulates EPOR expression, activates STAT5 signaling pathways, and enhances BCL-XL expression in a human preleukemic cell model. (A) Experimental schema: human CD34+ cells were isolated from normal cord blood and infected with an ETV6-RUNX1–expressing lentivirus. Cells were primed for B-cell differentiation for up to 5 days. (B) GFP+ (ETV6-RUNX1+) cells were analyzed for EPOR expression by FACS. EV indicates empty vector. (C) GFP+ (ETV6-RUNX1+) cells were analyzed for EPOR expression by Western blot. (D) GFP+ (ETV6-RUNX1+) cells were analyzed for BCL-XL expression and Western blot.

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