OS and RFS stratified by risk group and IDH1 SNP status in 186 adult AML patients. Kaplan-Meier estimates of (A) OS and (B) RFS are shown by risk group and, within the adverse risk group, IDH1 SNP status. Tick marks indicate censored observations. Among adult patients with adverse risk based on karyotype or FLT3/ITD, the IDH1 SNP was not significantly associated with OS (P = .94) or RFS (P = .28).