Figure 7
![Figure 7. Absence of T-bet and ROR[gamma]t does not alter donor antitumor (p815) response. Lethally irradiated (1200 cGy) B6D2F1 mice were transplanted with grafts from WT or RORγt−/−/T-bet−/− donors, containing 5 × 106 TCD-BM cells and 2-4 × 106 T cells from WT, T-bet−/−/RORγt−/− donors. No (A) or 4 × 103 P815 tumor cells (B-C) were added into donor graft. Survival by Kaplan-Meier analysis of B6D2F1 recipients (A-B) and mortality because of tumor relapse (C) are shown. Data are combined from 2 separate experiments (n = 13, TCD-BM + T-cell groups; n = 4, TCD-BM control group). Asterisk indicates statistical significance: *P < .05 and **P < .01.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/118/18/10.1182_blood-2011-03-340315/4/zh89991179650007.jpeg?Expires=1743175587&Signature=ipD0xaHXNwNEgUUZ2WhldLsLdkVe8aVOiKsY9m7MsUTvEWg3e0Wte6za6Guaqj5Ht0D4SrRN55Q3qmqDNbiKfm8Ok1iXzaaTn4lp8XwmsNDuH9cb4BYFMf0GkjuM5Iez9oKApIYsEqdC8dMJlvDWVTAdfkef3m0imXYCA6KRseWz0ZslEzmmO~uOSBhjdzqsqxL1wj6NK~VJQLTPBaOHGqfq-0ML8A16nD91~WxQkIoV8MzkeZrGG9lEfI4Rg7FA8ltVRTF4HEQ19G~q78MJk6ZNg5Ldj06OZDZW4JVK06uZMnFN-jBLs6UyEeiPNIEgtWt8ISMsm~i6yVTVp4pWVQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Absence of T-bet and ROR[gamma]t does not alter donor antitumor (p815) response. Lethally irradiated (1200 cGy) B6D2F1 mice were transplanted with grafts from WT or RORγt−/−/T-bet−/− donors, containing 5 × 106 TCD-BM cells and 2-4 × 106 T cells from WT, T-bet−/−/RORγt−/− donors. No (A) or 4 × 103 P815 tumor cells (B-C) were added into donor graft. Survival by Kaplan-Meier analysis of B6D2F1 recipients (A-B) and mortality because of tumor relapse (C) are shown. Data are combined from 2 separate experiments (n = 13, TCD-BM + T-cell groups; n = 4, TCD-BM control group). Asterisk indicates statistical significance: *P < .05 and **P < .01.
