Identification of mRNAs that are regulated by miR155 in DCs. (A) Microarray experiments were performed to compare the gene-expression profiles of mature LPS-treated BM-DCs from WT and miR155^−/− mice. The 3′UTRs of mRNAs that were significantly up-regulated in miR155^−/− DCs were analyzed for the presence of potential target sites of all mouse miRNAs using 4 prediction models (all seeds, conserved seeds, Targetscan 4, and ΔG duplex). The graphs represent the fold enrichment of target sites for each miRNA. The position of miR155 and its ranking with respect to target-site enrichment are indicated for each graph. (B) Microarray data for mature LPS-treated BM-DCs from WT and miR155^−/− mice are represented as a scatter plot showing average normalized signal intensities derived from 3 independent experiments. Each dot represents a probe set corresponding to one mRNA. Only dots corresponding to mRNAs exhibiting greater than a 1.5-fold difference in expression between the 2 genotypes are shown. Dots corresponding to Picalm, c-Fos, Pu.1, Ship, and Smad5 mRNAs are indicated. (C) Microarray experiments were performed to compare the gene-expression profiles of control and BIC-transduced DC²¹¹⁴ cells. Results are represented as a scatter plot showing average normalized signal intensities derived from 3 independent experiments. Each dot represents a probe set corresponding to one mRNA. Only dots corresponding to mRNAs exhibiting greater than a 1.5-fold difference in expression between control and BIC-transduced cells are indicated. The dot corresponding to c-Fos mRNA is indicated.