Figure 2
Souris, but not beigeJ, mice develop HLH after LCMV infection.BeigeJ, souris, PKO, and wild-type C57BL/6 mice were infected with 200 pfu LCMV intravenously. Body weight (A) and temperature (B) were monitored daily. Graphs represent mean ± SD of 2 independent experiments with 3 to 5 mice per group. The dashed line indicates the detection limit. (C) On day 12 after infection, blood counts were determined. Gray areas represent the range of blood count values obtained in naive C57BL/6 mice. (D-G) Serum levels of ferritin (D), sCD25 (E), IFN-γ (F), and triglycerides (G) were determined on day 12 after LCMV infection. n.s. indicates not significant (P > .05). **P < .01. ***P < .001.
