Figure 3
Figure 3. Souris mice display histopathologic features of HLH after LCMV infection. BeigeJ, souris, PKO, and wild-type C57BL/6 mice were infected with 200 pfu LCMV intravenously. (A) Spleen weight in percentage of body weight and (B) serum levels of liver enzymes on day 12 after LCMV infection. Pooled data from at least 2 independent experiments with 3 to 5 mice per group. n.s. indicates not significant (P > .05). ***P < .001. (C) Representative pictures of liver sections stained with anti-F4/80 (original magnification × 10). Lower left inset: A semiquantitative analysis of hemophagocytosis by macrophages as assessed in 10 high power visual fields (40×) per mouse. (+) indicates rare; +, few; and +++, very frequent. Scale bars represent 100 μm.

Souris mice display histopathologic features of HLH after LCMV infection.BeigeJ, souris, PKO, and wild-type C57BL/6 mice were infected with 200 pfu LCMV intravenously. (A) Spleen weight in percentage of body weight and (B) serum levels of liver enzymes on day 12 after LCMV infection. Pooled data from at least 2 independent experiments with 3 to 5 mice per group. n.s. indicates not significant (P > .05). ***P < .001. (C) Representative pictures of liver sections stained with anti-F4/80 (original magnification × 10). Lower left inset: A semiquantitative analysis of hemophagocytosis by macrophages as assessed in 10 high power visual fields (40×) per mouse. (+) indicates rare; +, few; and +++, very frequent. Scale bars represent 100 μm.

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