IL-2 affects the transcriptional profile of TRAIL and Nab2 in helpless CD8+ T cells. Purified CD8+ T cells isolated from helped (filled bars) or helpless mice (open bars) were restimulated with the E1B192-200 peptide in the absence or presence of 20 CU/mL of recombinant human IL-2 or were left untreated. The relative mRNA expression of TRAIL (A), Nab2 (B), and IFNγ (C) was determined by RT-PCR (T cells were pooled from 3-4 mice per group and data shown are representative of 3 experiments). **P < .02; ***P < .005.