Atherosclerotic lesion formation is attenuated by PRT060318. (A) Digital photograph (D70S camera [Nikon] with Tamron SP AF90mm F/2.8 Di Macro 1:1 lens) of Sudan IV staining of longitudinally opened and pinned thoraco-abdominal aortas harvested from ApoE^−/− mice after 20 weeks of high-fat feeding. PRT060318 (30 mg/kg in distilled water; n = 15) or vehicle control (n = 16) were administered via oral gavage twice daily for 3 weeks followed by 1 week off, for a total of 16 weeks. (B) Quantification of percentage of lesion area in the descending thoracic and abdominal aorta as assessed by Sudan IV staining and computer-assisted imaging analysis.