Analysis of EKLF binding and mRNA levels. EKLF peaks were assigned to the nearest gene to generate a list of EKLF target genes, which was compared with the genes showing differences in transcript levels between progenitor cells and erythroblasts. (A) A table showing the number of EKLF target genes whose mRNA level changes between the progenitor cell and erythroblast populations. EKLF target genes are divided into those that are specific to progenitor cells, specific to erythroblasts, or common to both populations. (B) EKLF occupancy and mRNA expression in the mouse Cd44 locus. The UCSC browser shows the organization of the Cd44 locus and direction of transcription at the top. The mRNA Pro RNA and mRNA Ery RNA tracks represent the RNA-Seq reads derived from progenitor cells and erythroblasts, respectively, demonstrating higher levels of Cd44 mRNA in progenitor cells. The bars in the MACS Pro and MACS Ery tracks represent the EKLF peaks (at the p06 level of significance) identified by MACS in the progenitor cell and erythroblast chromatin, respectively. EKLF occupancy is only seen in progenitor cells.