Overlap of EKLF peaks with sites occupied by GATA1, GATA2, and TAL1. (A) Venn diagram of EKLF-occupied DNA fragments in primary progenitor cells and TAL1- and GATA2-occupied DNA segments in G1E cells (which do not express GATA1), showing minimal co-occupancy of the 3 transcription factors. (B) Venn diagram of EKLF-occupied DNA fragments in primary erythroblasts and TAL1- and GATA1-occupied DNA segments in induced G1E-ER4 + E2 cells, showing significant co-occupancy by GATA1 and TAL1, and much less overlap with EKLF.