Three-dimensional reconstructions of confocal microscopy images of TNF-α–activated venules of cremaster microcirculation from WT (top) and EHCgp130^–/– mice (bottom). Adherent neutrophils are shown in green. Note that in venules of WT mice, the luminal side has many adherent neutrophils and the basolateral side contains several neutrophils that have exited the vessel. Most neutrophils have migrated into the interstitial space well beyond the vessel. In contrast, the venules of the EHCgp130^−/− mice contains neutrophils adherent to the luminal surface but very few neutrophils that have exited the vessel. See Figure 5E in the article by Yao et al, which begins on page 3832.