Figure 1
Figure 1. Assembly of an integrated platelet network. Data from various sources were combined, creating a comprehensive network, which serves as a foundation for the integrated network analysis of signaling pathways, kinase distribution, and functional enrichment in platelets. A comprehensive resource of human platelets was created using data from protein-protein interactions and modifications complemented with drug and disease association data, pathway information, kinase-substrate data, and predictions for kinases and transmembrane domains. Based on this, a systems biology workbench was created for easy access to platelet proteins and their related information. Subnetwork extraction allows in-depth analysis of multiple proteins with their modification type, kinase-substrate relationships, and drug association.

Assembly of an integrated platelet network. Data from various sources were combined, creating a comprehensive network, which serves as a foundation for the integrated network analysis of signaling pathways, kinase distribution, and functional enrichment in platelets. A comprehensive resource of human platelets was created using data from protein-protein interactions and modifications complemented with drug and disease association data, pathway information, kinase-substrate data, and predictions for kinases and transmembrane domains. Based on this, a systems biology workbench was created for easy access to platelet proteins and their related information. Subnetwork extraction allows in-depth analysis of multiple proteins with their modification type, kinase-substrate relationships, and drug association.

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