Figure 3
Figure 3. IR-induced changes in the cellularity of the stroma are dependent on their stromal cell type and ink4a/arf status. Absolute cell counts of BM-SC (A,D), OB-SC (B,E), and hematopoietic cell (C,F) populations collected from femurs of wild-type (WT) and Ink4a/arf-deficient (KO) mice were determined by flow cytometry (see “Methods”) after exposure (IR) or not (CTR) to 6 Gy of IR. BM-SC and hematopoietic cell counts were evaluated in each femur OB-SC cell counts were evaluated from both femurs collected from the same mouse. n = 11-21 mice per group. *P < .05 by Student t test.

IR-induced changes in the cellularity of the stroma are dependent on their stromal cell type and ink4a/arf status. Absolute cell counts of BM-SC (A,D), OB-SC (B,E), and hematopoietic cell (C,F) populations collected from femurs of wild-type (WT) and Ink4a/arf-deficient (KO) mice were determined by flow cytometry (see “Methods”) after exposure (IR) or not (CTR) to 6 Gy of IR. BM-SC and hematopoietic cell counts were evaluated in each femur OB-SC cell counts were evaluated from both femurs collected from the same mouse. n = 11-21 mice per group. *P < .05 by Student t test.

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