EZH2^Y641F enhances proliferation in combination with Eµ-Myc. (A) Quantitative analysis of the cell-cycle distribution in the bone marrow and spleen of WT, EZH2^Y641F, Eµ-Myc, and Eµ-Myc/EZH2^Y641F mice based on in vivo BrdU incorporation. Analysis was based on flow cytometry and gated on the respective subpopulation. (B) Representative flow cytometric plots analyzed for 7-aminoactinomycin D (7AAD) and BrdU gated on B220⁺ spleen cells in WT, EZH2^Y641F, Eµ-Myc, and Eµ-Myc/EZH2^Y641F mice.