Removal of Nrf2 accelerates the reduction of B-cell number caused by Trsp gene loss but promotes immunoglobulin production. (A-B) Flow cytometric analysis of B cells (B220⁺/CD19⁺) in bone marrow (A) and spleen (B) of Trsp^fl/del and Trsp^fl/del:Mx1-Cre mice on an Nrf2^+/+ or Nrf2^–/– background. Representative data are presented from more than 3 independent experiments. (C) Serum immunoglobulin concentrations from Nrf2^+/+:Trsp^fl/del (open circles), Nrf2^+/+:Trsp^fl/del:Mx1-Cre (open triangles), Nrf2^–/–:Trsp^fl/del (closed circles), and Nrf2^–/–:Trsp^fl/del:Mx1-Cre (closed triangles). Horizontal bars indicate average means (*P < .005).