Treatment algorithm for CLL patients in frontline (A) and second-line (B) indications. Al indicates alemtuzumab; R, rituximab; O, ofatumumab; F, fludarabine; C, cyclophosphamide; Mab, monoclonal antibody; Dex, dexamethasone; and Allo-SCT, allogeneic stem cell transplantation. Please note that performing an allogeneic transplantation usually requires the induction of a PR or CR before the procedure.