American Society of Hematology

Figure 2

$Figure 2. Deficiency of gp130 in endothelial cells causes rolling neutrophils to arrest in trauma-stimulated venules. Neutrophil rolling flux fractions and firm adhesion were measured in trauma-stimulated venules of cremaster muscle. (A-B) Data from chimeras generated by transplanting bone marrow cells of the indicated genotype into irradiated recipient mice of the indicated genotype. (C-D) Data from WT and MCgp130−/− mice. (E-F) PKH26-labeled donor leukocytes of the indicated genotype were injected intravenously into recipient mice of the indicated genotype. Rolling and firm adhesion of the injected cells was measured by fluorescence microscopy. The data represent the mean ± SEM from 15 to 20 venules from 4 to 5 mice in each group. *P < .05, **P < .01.$

Deficiency of gp130 in endothelial cells causes rolling neutrophils to arrest in trauma-stimulated venules. Neutrophil rolling flux fractions and firm adhesion were measured in trauma-stimulated venules of cremaster muscle. (A-B) Data from chimeras generated by transplanting bone marrow cells of the indicated genotype into irradiated recipient mice of the indicated genotype. (C-D) Data from WT and MCgp130^−/− mice. (E-F) PKH26-labeled donor leukocytes of the indicated genotype were injected intravenously into recipient mice of the indicated genotype. Rolling and firm adhesion of the injected cells was measured by fluorescence microscopy. The data represent the mean ± SEM from 15 to 20 venules from 4 to 5 mice in each group. *P < .05, **P < .01.

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