Platelets are increasingly recognized as participating in the inflammatory response in addition to their well-characterized role in hemostasis and thrombosis. Depicted in a conceptual triangle is a platelet-leukocyte balance supporting normal homeostasis. In the condition of sepsis, significant dysregulation of a platelet-leukocyte balance occurs. In the study by de Stoppelaar et al,¹  the significance of the platelet is further defined in septic animals with experimentally induced thrombocytopenia. The dysregulation of the septic triad leads to an additional imbalance between infection, inflammation, and hemostasis/thrombosis.