CHAI and LATAIE disease phenotype and mechanism. (A) Clinical features of CHAI and LATAIE disease. (B) Schematic of the CTLA4 exons showing the mutations in CHAI patients. TM, transmembrane domain. A schematic displaying LRBA mutations causing LATAIE can be found in Lo et al,¹²  Alkhairy et al,¹⁷  and Gámez-Díaz et al.¹⁸  (C) Model depicting the function of CTLA-4 and its regulation by LRBA.