Figure 3
![Figure 3. Transfused VWF fragments exhibit t1/2 of ∼1 to ∼4 hours (hrs). PPP isolated from hydrodynamically injected Vwf−/− mice (n = 5-11 mice per VWF fragment) by cardiac puncture was pooled and transfused into 4 to 9 naive Vwf−/− mice. Residual VWF levels (mean ± SD) in recipient mice were normalized to the 5-minute time point (set as 100% [%5min]). Measurements were nonlinearly regressed to predict the clearance of each FVIII-stabilizing VWF fragment (curves).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/124/3/10.1182_blood-2013-11-540534/4/445f3.jpeg?Expires=1735579821&Signature=e79VTXNj79HWx0OQ9U7yxkLONYjZ4INjS~0DgvoiRMJIIHzI7~o5Fn5kgrIvDcyd-lqzwBffrf8jv9Sb3L7aFPEWQnIpRNQmpJC7tqayWb3Y1jEQUeuJfzdOP08n8rptdtGnoYIT9g8l-BAOhQpvuuPtbl2hQiFgQoePoEwpuOtAmJmj4TX-A7lykCZoEJ0JHIGF~BHxTuVSn08NZ7oV6dO6hApV5nmEFmkvoK0J7LNx4Bgbc0Ksa3nJMawWoYiHXpUre75zpfhNd~J0ZwaBG-fKn2yWIpPt6OqYXGfJlfhqB1Y0WLqieQq436gFTY3T-lmQoUZjAkzqsUAO3~1WIw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Transfused VWF fragments exhibit t1/2 of ∼1 to ∼4 hours (hrs). PPP isolated from hydrodynamically injected Vwf−/− mice (n = 5-11 mice per VWF fragment) by cardiac puncture was pooled and transfused into 4 to 9 naive Vwf−/− mice. Residual VWF levels (mean ± SD) in recipient mice were normalized to the 5-minute time point (set as 100% [%5min]). Measurements were nonlinearly regressed to predict the clearance of each FVIII-stabilizing VWF fragment (curves).
