Figure 3
M-CSF macrophages phagocytose mainly through FcγRIIa, whereas GM-CSF macrophages phagocytose mainly through FcγRI. Effect of FcγR receptor blocking F(ab′)2 (α-FcγRI, α-FcγRIIa,b, α-FcγRIII) or Fab (α-FcγRIIb) fragments on the phagocytosis of anti-RhD IgG-opsonized erythrocytes. Data are normalized against phagocytosis of unblocked macrophages. For experiments with Fab α-FcγRIIb individuals with an FCGR2C-open reading frame are excluded. Data represent means and standard error of the mean from 5 to 12 independent experiments. P values indicate results of 1-way ANOVA; subsequent unpaired t-tests were performed with results depicted as follows: *P < .05, **P < .01, ***P < .001 (Bonferroni-corrected P values).
