NAC reduces the size and activity of soluble VWF multimers in plasma. NHP, normal mouse plasma (NMP), and normal baboon plasma (NBP) was incubated with NAC, and VWF multimer composition was analyzed in NHP (A), NMP (C), and NBP (E). The percentage of VWF multimers was calculated using densitometric analysis of NHP (B), NMP (D), and NBP (F). The detection limit of the VWF multimer analysis was limited to multimers, and therefore the monomers obtained when incubating NMP with NAC are not visible on the gel. Each bar on the graphs represents the mean and standard deviation from 3 measurements. HMW, high molecular weight; LMW, low molecular weight; MMW, medium molecular weight.