Mouse T-ALL cell lines with high ZEB2 levels are sensitive to KDM1A inhibition. (A) Leukemic cell survival of P53/R26-Zeb2^tg/tg Zeb2 overexpressing mouse T-ALL cell lines compared with control P53/R26^+/+ cell lines treated with different concentrations of the KDM1A inhibitor GSK2879552 for 4 days. The average of 3 independent experiments and standard deviation is plotted. (B) Effects of exogenous IL-7 on the KDM1A inhibitor-induced cell death observed in P53/R26-Zeb2^tg/tg Zeb2 overexpressing mouse T-ALL cell lines. Average of technical triplicates are plotted. Similar effects are observed with the second independent mouse T-ALL cell lines. (C) Differential gene expression after KDM1A inhibition (24 hours, 100 nM GSK2879552) in P53/R26^+/+ and P53/R26-Zeb2^tg/tg mouse T-ALL cell lines (adjusted P value <.05, triplicates). (D) Overlap between the KDM1A responsive gene signatures in P53/R26^+/+ and P53/R26-Zeb2^tg/tg mouse T-ALL cell lines.