BDMV clearance required the integrin-binding domain of lactadherin. (A) The transmigration of PKH26-labeled BDMVs through activated endothelial cells in the presence and absence of lactadherin and monocytes (n = 15, 1-way ANOVA). C57BL/6J mice (n = 16) were preconditioned with an equal molar concentration of either lactadherin or its C1C2 domain (PBS as control) before being subjected to FPI. They were then examined for plasma levels of (B) NSE⁺ MVs, (C) mtMVs, (D) clotting time, and (E) plasma levels of d-dimer. Data presented in C-F were analyzed with repeated measures ANOVA, *P < .01 and **P < .001 vs PBS-injected mice.