Cereblon-bound IMiDs cause oxidative stress by inhibition of key enzymes of intracellular H₂O₂ decomposition, leading to immunoglobulin dimerization, thereby resulting in proapoptotic endoplasmic reticulum (ER) stress. Measuring the antioxidative capacity can predict IMiD sensitivity in MM cells. Ig, immunoglobulin. See Figure 7J in the article by Sebastian et al that begins on page 991.